The creator of Comic Sans, Vincent Connare, revealing the irony of it:
Comic Sans was NOT designed as a typeface but as a solution to a problem with the often overlooked part of a computer program’s interface, the typeface used to communicate the message.
There was no intention to include the font in other applications other than those designed for children when I designed Comic Sans. The inspiration came at the shock of seeing Times New Roman used in an inappropriate way.
He also has this presentation dubbed I hate Comic Sans (pdf)
Nice article over at i love typography about what to have in mind when choosing a typeface for your project, whether it’s for web or print.
On choosing type - First principles:
Before we get to the nitty-gritty of choosing type, let’s briefly talk about responsibility. Fundamentally, the responsibility we bear is two-fold: first we owe it to the reader not to hinder their reading pleasure, but to aid it; second, we owe a responsibility to the typeface or typefaces we employ. Good typefaces are designed for a good purpose, but not even the very best types are suited to every situation. Personally, I’m always a little nervous about using a newly acquired typeface. A new typeface is something like a newborn baby (though it doesn’t throw-up on you): don’t drop it, squeeze it too hard, hold it upside-down; in other words, don’t abuse it, treat it respectfully, carefully.